Safety is critical. Use chemical-resistant gloves, eye protection, and work in well-ventilated areas. Methanol is toxic and flammable—store it in sealed containers away from heat. Always add chemicals to oil slowly to prevent splashing. The GlobeCore USB system enhances safety with enclosed reaction chambers, automated chemical dosing, and built-in emergency shut-off features. Operators should receive basic hazardous material training and ensure proper waste handling, particularly of glycerin and used methanol.